Caroline N Nelson The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2013

Caroline N Nelson

Research Officer, Institute for Molecular Bioscience, University of Queensland, Queensland, Australia Caroline Nelson recently completed her PhD at the Institute for Molecular Bioscience at the University of Queensland with Professor Michael Waters. Her research focus is on elucidating the molecular mechanisms of the anti-obesity effects of growth hormone. Using knockin mouse models with various truncations to the growth hormone receptor, Caroline has found that loss of activation of the transcription factor, STAT5 by growth hormone is central to the development of hepatosteatosis and obesity in the absence of growth hormone signalling. She has recently discovered that the more oxidative beige, or brite ("brown in white"), fat development is also impaired in these mutant mice, providing a novel mechanism by which growth hormone (via STAT5 activation) exerts it's anti-obesity effects.

Abstracts this author is presenting: